Brillouin Capillaroscopy

Brillouin microscopy probes the viscoelastic properties of tissue without contact or labels, by reading the frequency shift of light scattered from spontaneous acoustic waves. Capillaroscopy applies this to the dense, dynamic network of capillaries near the skin surface.

The goal is a compact, clinic-ready instrument that maps capillary stiffness as an early biomarker — combining a confocal Brillouin probe with motion-tolerant acquisition and analysis.

Contributions

1. Designed the confocal optical train and probe geometry for surface capillary access.
2. Developed motion-tolerant acquisition to suppress pulsatile and respiratory artifacts.
3. Built the analysis pipeline mapping Brillouin shift to capillary mechanical contrast.